Cykin is low cost generic of Palbociclib (PD-0332991) in Bangladesh. Cykin (Palbociclib, PD-0332991) is a kinase inhibitor for oral administration in Hormone receptor positive breast cancer. Cykin the latest generic of IBRANCE (Pfizer) is indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in combination with: 1. an aromatase inhibitor as initial endocrine based therapy in postmenopausal women; or 2. fulvestrant in women with disease progression following endocrine therapy. Genvio Pharma Limited, a renowned pharmaceutical company in Bangladesh is manufacturing Cykin, the generic of Palbociclib and providing a quality product at an affordable price to the patients globally. The low cost generic of IBRANCE (Palbociclib), Cykin is an inhibitor of cyclin-dependent kinases (CDK) 4 and 6. Cyclin D1 and CDK4/6 are downstream of signaling pathways which lead to cellular proliferation. Cykin (Palbociclib) 125 mg is available in 28’s pack size. The recommended dose of Cykin (Palbociclib, PD-0332991) is 125 mg once daily taken with food for 21 days followed by 7 days off treatment. Dosing interruption and/or dose reductions are recommended based on individual safety and tolerability. In case of breast cancer, hormone receptor (HR- positive) positivity, HER-2 and BRCA 1, BRCA 2 all these molecular profiles are very important. Treatment pattern basically depends on these issues. When it’s about hormone receptor positive and HER-2 negative breast cancer, Cykin (Palbociclib, PD-0332991) is one of better option with an aromatase inhibitor like letrozole. Each Cykin box contains patient medication information’s so before starting medication please go through the leaflet or download from Cykin (Palbociclib, generic of IBRANCE) website ( Genvio Pharma Limited takes pride in manufacturing quality medicine by adhering to the current Good Manufacturing Practice (cGMP) to meet the international standard. Being one of the top anti-cancer medicine manufacturers in Bangladesh, Genvio Pharma is committed to manufacture better alternatives of research molecules at an affordable price. So Genvio keeps the cost of IBRANCE generic, “Cykin” comparatively lower than the cost of IBRANCE (Pfizer) for the patient who cannot afford IBRANCE treatment.